ackground : peripheral neuropathy is one of the important complication of patient with diabetes mellitus and chronic renal failure. But its pathogenesis and frequency has not been clearly verified.
Methods : we measured amplitudes and conduction velocities of peroneal and sural nerve to
evaluate the effect of diabetes, proteinuria and renal insufficiency on the peripheral
neuropathy in patients with diabetic nephropathy.
Results :
1) the amplitude (5.8±1.3 uV) and conduction velocity (22.1±4.1m/sec ) of sural nerve in
DM group were significantly decreased compared with those (16.6±7.5 uV, 48.7±5.1 m/sec)
in normal control group (each other p<0.05, p<0.01).
2) the amplitude (2.1±0.6 uV) and conduction velocity (34.7±4.2 m/sec) of peroneal nerve in
DM group were significantly decreased compared with those (5.1±2.0 uV, 52.0±6.2 m/sec)
in normal control group (each other P<0.05).
3) the amplitude (3.8±2.1 uV) of surl nerve in renal insufficiency group tended to be
decreased compared with those in normal renal function group(5.2±2.5uV) and DM without
nephropathy group (8.3±3.2 uV).
4) the amplitude of peroneal nerve in renal insufficiency group (1.1±0.2 uV) and norman
renal function group (2.2±0.5 uV) were significantly decreased compared with tht in normal
control group (5.1±2.0 uV) (p<0.05), but not in DM without nephropathy (3.0±1.6 uV).
5) the conduction velocity of sural nerve in renal insfufficiency group(12.1±6.3 m/sec) and
normal renal function group (12.8±4.9 m/sec) were significantly decreased compared with
those of normal control group (48.7±5.1 m/sec) (P<0.05) and DM without nephropathy group
(41.3±6.6 m/sec) (P<0.05).
6) the conduction velocity of peroneal nerve in renal insfufficiency group (29.1±3.9 m/sec) and
normal renal function group (31.5±4.3 m/sec) were significantly decreased compared with
that of normal control group (52.0±6.2 m/sec) (P<0.05), but not in DM without
nephropathy (42.9±5.1 m/sec).
7) there was a significant correlation between HbA1C and nerve conduction velocity in
patients with diabetic nephropathy.
Conclusion : these data suggest that the peripheral neuropathy, diagnosed by amplitude and
nerve conduction velocity, may occur more frequently in patients diabetes mellitus
withou nephropathy, whether renal insufficiency was or not.
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